Search Result

Search Results for " cathepsin l "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T21616	L-006235	L 006235	Cysteine Protease
	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.		Cysteine Protease
T27730	KGP94	KGP-94,KGP 94	Cysteine Protease
	KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).		Cysteine Protease
T38469	(Rac)-Z-Phe-Phe-FMK	Cathepsin L-IN-2	Beta Amyloid , Cysteine Protease
	(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .		Beta Amyloid , Cysteine Protease
T72569	Cathepsin L/S-IN-1
	Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and inv...
T6015	Cathepsin Inhibitor 1		Cysteine Protease
	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.		Cysteine Protease
T12909	SID 26681509		Cysteine Protease , Parasite
	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).		Cysteine Protease , Parasite
T13288	VBY-825		Cysteine Protease
	VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.		Cysteine Protease
T37504L	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E but not for B, H, or L. Cathepsin D and E FRET Substrate acetate can be used in mechanistic studies on cathepsins D and E studies...
T16089	MK-0674		Cysteine Protease
	MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.		Cysteine Protease
TP2056L	Acetyl-Calpastatin (184-210)(human) acetate	Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base )	Cysteine Protease
	Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively.		Cysteine Protease
T1850	Balicatib	AAE581	Cysteine Protease
	Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.		Cysteine Protease
T15641	K777	APC-3316	P450 , Cysteine Protease , CCR
	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ...		P450 , Cysteine Protease , CCR
T35753	Z-Phe-Tyr(tBu)-diazomethylketone
	Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.
T71275	CID16725315
	Thiocarbazate, also known as CID16725315, is an inhibitor of human cathepsin L. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection. With respect to th...
T16092	L-873724		Others
	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respective...		Others
T80105	Z-Phe-Phe-Diazomethylketone
	Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L [1].
T71618	Oxocarbazate
	Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM ...
T26938	CAA0225	CAA 0225,CAA-0225
	CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.
T40463	Relacatib	SB-462795
	Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac...
T81265	RKLLW-NH2
	RKLLW-NH2 is an inhibitor of the protease Cathepsin L [1].
T80739	Z-FG-NHO-BzOME
	Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S, and papain [1].
T41236	Z-FY-CHO
	Z-FY-CHO (Z-Phe-Tyr-CHO) is a specific and potent cathepsin L (CTSL) inhibitor [1] [2].
T78186	Ac-VLPE-FMK	Ac-Val-Leu-Pro-Glu(OMe)-CH2F
	Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), functions as an inhibitor of both Cathepsin B (Cat-B) and Cathepsin L (Cat-L), and is utilized in research pertaining to the aggressiveness of cancer [1] [2]...
T37053	Z-(L-Arg)-AMC (hydrochloride)
	Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can b...
T38254	Cathepsin D and E FRET Substrate acetate
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, without activity towards cathepsins B, H, or L. This specificity makes it an essent...
T36942	SSAA09E1	SSAA09E1
	SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based ...
T73554	SPR38
	SPR38, a potent inhibitor of the SARS-CoV-2 main protease, exhibits a Ki value of 0.260 μM. Additionally, it effectively inhibits human cathepsin L (hCatL) and human cathepsin B (hCatB), displaying Ki values of 1.92 μM a...
T73553	SPR39
	SPR39, a potent inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrates inhibitory Ki values of 0.252 µM for SARS-CoV-2 Mpro, and 3.38 and 7.88 µM for human Cathepsin L (hCatL) and human Cathepsin B (hCatB) respec...
T63831	SID 26681509 quarterhydrate
	SID 26681509 quarterhydrate is a reversible, potent, selective, competitive inhibitor of human cathepsin L (IC50: 56 nM). SID 26681509 inhibits in vitro propagation of Plasmodium falciparum (IC50: 15.4 μM) and inhibits L...
TP2056	Acetyl-Calpastatin(184-210)(human)	Acetyl-Calpastatin (184-210) (human)
	Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
T75794	Acetyl-Calpastatin(184-210)(human) TFA
	Acetyl-Calpastatin(184-210)(human) TFA, a potent, selective, and reversible inhibitor of calpain, demonstrates Ki values of 0.2 nM for µ-calpain and 6 μM for cathepsin L, indicating high specificity and efficacy in inhib...
T73395	ASPER-29
	ASPER-29, an analog of Asperphenamate, acts as a dual inhibitor of cathepsin L and S, displaying inhibitory concentrations (IC50) of 6.03 μM and 5.02 μM, respectively. This compound is utilized in the study of cancer mig...
T62494	Cathepsin C-IN-5
	Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active inhibitor of Cathepsin C, demonstrating IC50 values of 59.9 nM for Cat C, and showing significantly lower potency against Cat L (4.26 µM), Cat S,...
T72446	SARS-CoV-2 Mpro-IN-4
	SARS-CoV-2 Mpro-IN-4 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL), exhibiting inhibition concentrations (IC50) of 900 nM and 60 nM, respectively. It demonstrates antiviral activity by effect...
T72447	SARS-CoV-2 Mpro-IN-5
	SARS-CoV-2 Mpro-IN-5 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL) with IC50 values of 1800 nM and 145 nM, respectively. This compound demonstrates antiviral activity by inhibiting SARS-CoV-2...
T11864	Iptacopan	LNP023	Others
	Iptacopan (LNP023) is an inhibitor with high affinity for factor B.		Others

Compounds

L-006235

T21616

Synonym: L 006235

Target: Cysteine Protease

KGP94

T27730

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

(Rac)-Z-Phe-Phe-FMK

T38469

Synonym: Cathepsin L-IN-2

Target: Beta Amyloid, Cysteine Protease

Cathepsin Inhibitor 1

T6015

Synonym:

Target: Cysteine Protease

SID 26681509

T12909

Synonym:

Target: Cysteine Protease, Parasite

VBY-825

T13288

Synonym:

Target: Cysteine Protease

Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

T37504L

Synonym: Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

Target: Cysteine Protease

Acetyl-Calpastatin (184-210)(human) acetate

TP2056L

Synonym: Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base )

Target: Cysteine Protease

Balicatib

T1850

Synonym: AAE581

Target: Cysteine Protease

K777

T15641

Synonym: APC-3316

Target: P450, Cysteine Protease, CCR

Z-Phe-Tyr(tBu)-diazomethylketone

Z-Phe-Phe-Diazomethylketone

Synonym: CAA 0225,CAA-0225

Synonym: Ac-Val-Leu-Pro-Glu(OMe)-CH2F

Target:

Z-(L-Arg)-AMC (hydrochloride)

T37053

Synonym:

Target:

Cathepsin D and E FRET Substrate acetate

SID 26681509 quarterhydrate

T63831

Synonym:

Target:

Acetyl-Calpastatin(184-210)(human)

TP2056

Synonym: Acetyl-Calpastatin (184-210) (human)

Target:

Acetyl-Calpastatin(184-210)(human) TFA

Cat No.	Product Name	Synonyms	Targets
TJS2216	Aurantiamide acetate	Asperglaucide	Cysteine Protease
	Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide aceta...		Cysteine Protease
T6564	Leupeptin Hemisulfate		Serine Protease , Cysteine Protease
	Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc...		Serine Protease , Cysteine Protease
TN1249	3-Epiursolic acid		Cysteine Protease , Immunology/Inflammation related
	3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered p...		Cysteine Protease , Immunology/Inflammation related
T19392	L-Homocysteine		Others
	L-Homocysteine, an L-configured homocysteine metabolite, induces the upregulation of cathepsin V, which mediates vascular endothelial inflammation in hyperhomocysteinaemia.		Others
T72898	Gallinamide A
	Gallinamide A is a potent inhibitor of cathepsin L with an IC 50 value of 17.6 pM.

Natural Products

Aurantiamide acetate

TJS2216

Synonym: Asperglaucide

Target: Cysteine Protease

Leupeptin Hemisulfate

T6564

Synonym:

Target: Serine Protease, Cysteine Protease

3-Epiursolic acid

TN1249

Synonym:

Target: Cysteine Protease, Immunology/Inflammation related

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02171	Cathepsin L Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin L Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is P06797.
TMPY-00734	Cathepsin L Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin L Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is A0A024R276.
TMPJ-00508	CTSL Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tu...
TMPY-01249	Cathepsin V Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t...
TMPJ-00708	CST7 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mouse Cystatin F belongs to cystatin superfamily, which encompasses proteins that contain multiple cystatin-like sequences. It has been shown that Cystatin F is selectively expressed by hematopoietic cells and may be a b...
TMPJ-00497	CTSB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, bot...
TMPY-00729	Cystatin D Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stef...